In search of lost hybridity: the French Daniel Deronda

Starting from a set of examples of borrowings from French in George Eliot’s Daniel Deronda, I explore the various ways in which the characters’ and narrator’s use of mixed English–French utterances generates inferences which make the transcending of their mono-cultural self possible. I go on to argue that in Jumeau’s recent French translation of the novel, the reader is not given access to those inferences, resulting in the erasing of an Anglo-European, cosmopolitan identity

‘George Eliot’s French’: transcending the monocultural self in Daniel Deronda

Focusing on an analysis of French lexical items in George Eliot’s Daniel Deronda, this article examines the nature of composite textuality. More precisely, it proposes a way of describing the use of an intercultural idiom in Daniel Deronda as a way of shedding light on the nature of linguistic borrowing in the context of dialogical identity. This will provide the basis for the claim that the characters’ use of mixed utterances generates inferences which make the transcending of the monocultural self possible and create alternatives of being

Benjamin’s ‘flâneur’ and serial murder: An ultra-realist literary case study of Levi Bellfield

This article seeks to develop criminological theory with the application of a literary device known as the ‘flâneur’ – an individual described as a ‘stroller’ – to serial murderer Levi Bellfield. With this application of the ‘flâneur’ to the phenomenon of serial murder, this article provides a fresh theoretical ‘lens’, and specifically sheds light on how particular serial murderers operate and evade detection in modern society. The importance of modernity to the phenomenon of serial murder is also considered utilizing Ultra-Realist theory, resulting in both a micro and macro examination into how the modern urban landscape has subsequently created an environment in which the serial killer both operates and comes to fruition. This synthesis between the application of literary devices, criminological theory and socio-cultural concepts not only raises important and previously neglected questions pertaining to serial murder, but also assists in forming the more sinister relative of the flâneur: the ‘dark flâneur’

β-Catenin Loss in Hepatocytes Promotes Hepatocellular Cancer after Diethylnitrosamine and Phenobarbital Administration to Mice

Hepatocellular Carcinoma (HCC) is the fifth most common cancer worldwide. β-Catenin, the central orchestrator of the canonical Wnt pathway and a known oncogene is paramount in HCC pathogenesis. Administration of phenobarbital (PB) containing water (0.05% w/v) as tumor promoter following initial injected intraperitoneal (IP) diethylnitrosamine (DEN) injection (5 µg/gm body weight) as a tumor inducer is commonly used model to study HCC in mice. Herein, nine fifteen-day male β-catenin knockout mice (KO) and fifteen wild-type littermate controls (WT) underwent DEN/PB treatment and were examined for hepatic tumorigenesis at eight months. Paradoxically, a significantly higher tumor burden was observed in KO (p<0.05). Tumors in KO were β-catenin and glutamine synthetase negative and HGF/Met, EGFR & IGFR signaling was unremarkable. A significant increase in PDGFRα and its ligand PDGF-CC leading to increased phosphotyrosine-720-PDGFRα was observed in tumor-bearing KO mice (p<0.05). Simultaneously, these livers displayed increased cell death, stellate cell activation, hepatic fibrosis and cell proliferation. Further, PDGF-CC significantly induced hepatoma cell proliferation especially following β-catenin suppression. Our studies also demonstrate that the utilized DEN/PB protocol in the WT C57BL/6 mice did not select for β-catenin gene mutations during hepatocarcinogenesis. Thus, DEN/PB enhanced HCC in mice lacking β-catenin in the liver may be due to their ineptness at regulating cell survival, leading to enhanced fibrosis and regeneration through PDGFRα activation. β-Catenin downregulation also made hepatoma cells more sensitive to receptor tyrosine kinases and thus may be exploited for therapeutics